Sunday, December 29, 2019

Arbitrage Pricing Theory And Uk Stock Exchange Finance Essay - Free Essay Example

Sample details Pages: 17 Words: 5056 Downloads: 4 Date added: 2017/06/26 Category Finance Essay Type Research paper Did you like this example? To estimate empirically the Arbitrage Pricing Theory (APT) model we focus our attention to the UKs stock exchange market. Our study employs monthly time series data spanning the period 2000:9 to 2010:9 (121 observations). The sample of our analysis is dictated solely by the demands of the coursework. Don’t waste time! Our writers will create an original "Arbitrage Pricing Theory And Uk Stock Exchange Finance Essay" essay for you Create order The variables involved are: the closing share prices for 25 UK companies listed on the London Stock Exchange, the FTSE 100 stock index, the UK Libor as proxy for the short-run risk-free rate, the 20-year government bond yield as proxy for the long-run risk-free rate, the exchange rate series between the British Pound and the US Dollar and finally the Brent crude oil prices.  [1]  The abbreviated notation of the above variables is as follows: Sharei = Si with i= 1 to 25 FTSE 100 stock index = indext UK Libor= free_s_ratet 20-year government bond yield = free_l_ratet Exchange rate series = fxt Brent crude oil prices = brentt Given the availability of the Si series it is trivial to calculate the return series for each of the 25 selected shares (r_ Si) by taking the first logarithmic differences of the share prices (growth rate). To do so in E-views the relevant command is the one described below: For !i=1 to 25 series r_S!i = dlog(S!i) Next To constr uct the equally weighed portfolio return series (portfoliot) we merely estimate the average return of the 25 share returns for each time period of the sample. The commands applied are described as follows: series sum_stock_returns = r_S1+ r_S2+ r_S3+ r_s4+ r_S5+ r_S6+ r_S7+ r_S8+ r_S9+r_S10+r_S11 +r_S12+ r_S13+ r_S14+ r_S15+ r_S16+ r_S17+ r_S18+ r_S19+ r_S20+ r_S21+ r_s22+ r_S23+ r_S24+ r_S25 series portofolio = sum_stock_returns / 25 Figure 1 below presents the five main variables used in this study as well as the equally weighed portfolio return series constructed by the returns of the 25 involved shares. Figure 1. The variables of the study Figure 1. The variables of the study (continued) II. Empirical Results Question 1 i) The term spread is defined as the difference of the short-run and the long-run free interest rates. The relevant command is: series term_spread = free_l_rate free_s_rate, and the finally constructed series is illustrated in Figure 2. The mid-period of the sample (2003-2007) is characterized by healthy economic activity and therefore the term-spread decreased, while during the crisis (2008-2010) the short term rate is almost zero and as a result the term spread increased. Figure 2. The term-spread series ii) Figure 3 presents the percentage changes for the three basic factors of the model. The percentage change transformation for the term-spread series, the exchange rate series and the Brent oil prices is accomplished through the following three E-views commands: series g_term_spread = ( term_spread term_spread(-1) ) / term_spread(-1) series g_fx = ( fx fx(-1) ) / fx(-1) series g_brent = ( brent brent(-1) ) / brent(-1) Figure 3. Percentage changes for the th ree basic factors of the APT model In general, the three variables show similar characteristics with respect to their evolution through the observed sample period. In particular, the following distinctive characteristics are realized a) All the variables appear to fluctuate around a constant mean value, which in every case is approximately equal to zero, b) All the variables seem to have variance that remains fairly constant within the sample, but this is not the case for the exchange rate which becomes volatile after 2008, and the term-spread which has a very low volatility after 2009 (the short-term risk free rate is zero) c) All the variables receive extreme values approximately at the same period, which is located during the last quarter of 2008, d) Only the percentage change of the term-spread appears to present two additional extreme values one in the beginning of the sample and one just before the middle point of the sample. What can be inferred from the above is that all the variables show clearly a stationary behaviour. This stationarity can be verified by implementing relevant stationarity tests. By applying the Augmented Dickey Fuller test (ADF) we have realized that the three examined variables are undoubtedly stationary.  [2] iii) Figure 4 presents the portfolio excess returns over the short-run risk free proxy (exs_r_portofolio) along with a set of descriptive statistics.  [3]  The E-views command to construct the portfolio excess returns is presented beneath: series exs_r_portofolio = portofolio (free_s_rate/100) Figure 4. Portfolio excess returns and the associated descriptive statistics Similarly, figure 5 presents the market excess returns over the short-run risk free proxy (exs_r_index) along with a set of descriptive statistics (see footnote 3). The E-views command to construct initially the market returns and afterwards the market excess returns are presented below: series r_index = dlog(index) series exs_r_inde x = r_index (free_s_rate/100) Figure 5. Market excess returns and the associated descriptive statistics Before we comment on the distributional properties of these two variables, it is worth to mention that both variables appear to be stationary with constant mean and constant variance.  [4]  Again the applied ADF tests revealed that indeed both variables are clearly stationary.  [5]  What we know for the case of the symmetric distributions is that the mean and the median statistics are equal between them. Differences between these two measures occur with skewed distributions. In our case, the portfolio excess returns series appear to have almost identical values for the mean and the median statistics, that is -0.036483 and -0.036315 respectively, which is an indication for a symmetric behaviour. The maximum value is 0.14, the minimum value is -0.24 and finally the standard deviation receive the value of 0.057. Skewness measures the distributions asymmetry around t he mean. A symmetric distribution like the normal has skewness equal to 0, while positive skewness means that the distribution has a long right tail and negative skewness implies that the distribution has a long left tail. The value of -0.300 for the skewness implies that the distribution of the portfolio excess returns presents a slightly long left tail, which is a result of the negative returns during the crisis. Kurtosis measures the fatness of the distribution of the series. The kurtosis of the normal distribution is 3, while in cases where the kurtosis exceeds the said value, the distribution is leptokurtic relative to the normal; and if the kurtosis is less than 3, the distribution is platykurtic relative to the normal. The value of 4.67 for the Kurtosis implies that the distribution of the portfolio excess returns series is pretty leptokurtic. This is common for stock returns. Finally, we tested for normality by making use of the Jarque-Bera statistic. The null hypothesis in the test is that the distribution is normal. The estimated Jarque-Bera statistic along with the associated p-value, for the portfolio excess returns series, are 15.76 and 0.000, respectively. Consequently, judging by the reported p-value we clearly reject the null hypothesis of normality. Therefore, the portfolio excess returns series is not distributed normally. Provided that the Anderson-Darling normality test presents better small sample properties than the Jarque-Bera test, we implemented it also. The Anderson-Darling normality test has the same null hypothesis as the Jarque-Bera test. The Anderson-Darling test statistic receives the value of 24.13 with p-value 0.000, and as a result we reject the null hypothesis of normality. Overall, both tests affirm that the portfolio excess returns series is not distributed as a normal variable. The non-normality is a characteristic of small samples and in our case we only had 121 observations. If the sample size increases the distribution will be closer to the normal distribution. Furthermore, it is a well known fact that asset returns are not normally distributed. Turning now to the market excess returns series, we may say that the mean and the median of the series are quite similar, that is -0.042 and -0.039 respectively, indicating symmetric behaviour. The maximum value is 0.07, the minimum value of the series is -0.20 and finally the standard deviation receive the value of 0.05. The skewness is -0.31 and kurtosis is 3.66, indicating quite normal behaviour given that these two values are quite close to the benchmark values of the normal distribution (0 and 3, respectively). The p-value of the estimated Jarque-Bera statistic is 0.12, indicating that we fail to reject the null hypothesis of normality at the conventional 0.05 level of significance. Finally, the p-value of the estimated Anderson-Darling statistic is 0.06, indicating again that we fail to reject the null hypothesis of normality at the conventional 0 .05 level of significance. In general the market excess returns appear to distribute like a normal variable. What has been revealed from the above analysis is that a) both series are stationary, b) the market excess return series is less volatile than the portfolio excess returns series and c) the market excess return series is distributed normally, while this not true for the portfolio market excess return series. Question 2 In this section we estimate the APT model having as a dependent variable the excess portfolio returns and as independent variables 1) the excess market returns 2) the percentage change of the term spread 3) the percentage change of the exchange rate series and finally 4) the percentage change of the Brent crude oil prices. The specification of the above described APT model is provided by equation (1): (1) where, is the excess portfolio returns series at time t , c is the constant term, is the excess market returns series at time t, is the percentage change of the term spread at time t, is the percentage change of the exchange rate series at time t, is the percentage change of the Brent crude oil prices at time t, are parameters to be estimated and finally, is the error term assuming the usual properties. Parameter estimates for equation (1), by means of the OLS estimation technique, along with their associated standard errors, t-statistics and p-values, are analytically il lustrated in Table 1. The E-views command for the estimation of the above mentioned model is as follows: equation model1.ls exs_r_portofolio c exs_r_index g_term_spread g_fx g_brent Table 1. Estimation output for equation 1 Variable Coefficient Std. error t-Statistic p-value constant 0.008164 0.002893 2.822046 0.0056 [ Rm-Rf ]t 1.047768 0.043587 24.03840 0.0000 GTSt 0.001993 0.003167 0.629342 0.5304 GFXt 0.039145 0.086038 0.454976 0.6500 GBPt 0.005340 0.024816 0.215195 0.8300 Regression Diagnostic Statistics R-squared 0.844807 Mean dependent var -0.036483 Adjusted R-squared 0.839409 S.D. dependent var 0.057761 S.E. of regression 0.023147 Akaike info Criterion -4.653130 Log likelihood 284.1878 Schwarz criterion -4.536984 F-statistic 156.5033 Hannan-Quinn criter. -4.605962 Prob(F-statistic) 0.000000 Durbin-Watson stat. 1.927105 White hetero. Test 0.926993 LM test ser. cor. (2 lags) 0.203657 Whites test p-value 0.532800 LM test ser. cor. p-value 0.816000 Anderson-Darling nor. test 0.858200 LM test ser. cor. (8 lags) 0.521658 Anderson-Darling p-value 0.440800 LM test ser. cor. p-value 0.837900 In general, the estimated sign for every single parameter is theoretically meaningful, only two of the parameters appear to be statistically significant at the conventional level of 0.05 and finally, the model seems to fit the data pretty well. In more detail and in relation to the expected signs we stress the following: the excess return of a well diversified portfolio is expected to experience similar co-movements with the excess returns of the market. Therefore, the expected sign is positive as it happens in our case. As it is well known, the term spread variable is widely used by economists and the practitioners in order to predict the real economic activity. Given that the stock market generally follows real economic activity, then it comes that the expected sign for the term-spread variable would be positive. The estimated sign in our model for the term spread variable is also positive. For the exchange rate variable we know that a company may be affected by the changes in the exchange rates directly if its orientation has to do with the foreign trade or indirectly if its inputs or outputs are affected by the exchange rate. In the literature there is no consensus with respect to the expected sign. Some studies have shown that devaluation of the currency has a strong positive effect in the long-run for the stock prices and a negative effect in the short-run. In general, we have no reasons to expect a particular sign for the exchange rate variable. Our results suggest the effect of the exchange rate changes is positive. Finally, we know how crucial the price of oil is for the operation of all firms but again we do not expect an a priori sign for the returns of a portfolio. The sign might be positive if most of the firms in the portfolio experience profits by such an increase and negative if the opposite is true. Furthermore, oil prices may be seen as the expectation for the future inflation. The estimated sign in our model is again positive, which of course does not contradict the theoretical underpinnings of the APT model. Overall, all the estimated signs of the coefficients, which are presented in the second column of Table 1, are theoretically meaningful and this fact indicates that our model is well specified. Among the independent variables used only the constant and the excess market returns appear to be statistically significant even at the 0.01 significance level, while all the remaining variables are statistically insignificant. The significance for a coefficient can be affirmed by the corresponding t-statistic or alternatively by the associated p-value. The t-statistic is calculated by the ra tio of the estimated coefficient (column two) to the associated standard error (column three). If the absolute value of the t-statistic is greater than 2, then we may say that the coefficient is significant at the 0.05 significance level (but this is a rule of thumb). More accurate information with respect to the significance can be derived from the p-value. Hence, if the p-value is lower than the selected level of significance (e.g. 0.01), then the coefficient is considered significant at that particular level of significance. Provided that we only have the constant and one variable that are statistically significant, we continue by interpreting only the two respective coefficients. The constant can be interpreted as follows: if all the independent variables are simultaneously equal to zero then portfolios excess return is equal to 0.008. For the second coefficient we can say that if the excess market returns increase by 1 unit, then the portfolio excess return will be increased by 1.047 units, provided that all the other variables remain constant. Additionally, as it can be inferred by the value of the adjusted R-square (corrected with the degrees of freedom), which is 0.839, included into the model independent variables explain more that the 4/5 of the portfolios excess returns variability. At last, the value of the F-statistic for testing the joint significance of all the independent variables included in the model is pretty high (156.50) with the associated p-value to be in practice equal to zero. Therefore, we reject the null hypothesis () that all the coefficients are jointly insignificant at 0.05 significance level and we can support that there is at least one coefficient which is significantly different from zero. The F-statistic provides further evidence for the validity of the estimated APT model. Question 3 In this section we conduct diagnostic testing in order to assess our models statistical strength. For this reason we investigate by testing analogously if there is presence of multicollinearity, heteroskedasticity, serial correlation and finally non-normality in the residuals. Before the diagnostic testing, it is important to stress that all the regressors used in equation 1 are stationary and therefore we exclude the possibility of estimating a spurious regression. It is well known that the estimated results in cases where the regression is characterized as spurious, are meaningless and the statistical inference is worthless. Clearly, this is not the case for our estimated model presented in Table 1. Turning now to the diagnostic testing procedure, our first concern is to ensure that there is no presence of multicollinearity. The problem with multicollinearity is that it inflates the standard errors and therefore it is hard to assess the significance of the regressors used i n the model. Furthermore, we know that multicollinearity does not affect the efficiency of the estimated parameters. Provided that there is no availability of an official testing procedure for the detection of multicollinearity we make use of a practical solution. According to this approach evidence for multicollinearity would be a high correlation among the regressors. High value for the correlation coefficient is considered a value of above 0.8. For this reason we estimate the correlation coefficients for all the regressors involved in the estimation of equation 1. The correlation coefficients are illustrated in Table 2. Undoubtedly, the results in Table 2 reveal that all the correlation coefficients are well below the threshold value of 0.8 and as a consequence we may say that there is no evidence of multicollinearity for that particular set of regressors. Table 2. Correlation matrix for the regressors of the APT model Regressor [ Rm-Rf ]t GTSt GFXt GBPt [ Rm -Rf ]t 1.000 GTSt 0.124 1.000 GFXt 0.066 -0.048 1.000 GBPt 0.216** -0.029 0.379*** 1.000 Note: **, *** denote significance at the 0.05 and 0.01 significance level, respectively. We continue with testing for serial correlation. We know that the presence of serial correlation in a regression model leads to the underestimation of the standard errors and the coefficients and as a consequence hypothesis testing will direct us to incorrect conclusions. A widely used Statistic for testing first order serial correlation is the Durbin-Watson. If its value is close to 2 then this is evidence of no serial correlation. In Table 1, we observe that the Durbin-Watson statistic equals to 1.92 and as result we can support the absence of a first order serial correlation. In order to ensure that higher order serial correlation is also excluded from our model we implemented the Breusch-Godfrey Serial Correlation LM Test for two and eight lags. The Breusch-Godfrey LM statistics for two and eight lags along with the associated p-values ar e presented in Table 1. Based on the relevant p-values we fail to reject the null hypothesis of no serial correlation in each case, and as a result we may support that serial correlation, even in higher orders, is not a problem in our model. Another important issue related to the diagnostics of a model has to do with the presence of heteroskedasticity. Heteroskedasticity leads to non-efficient estimators as well as to biased standard errors, resulting to unreliable t-statistics and confidence intervals. However, the estimators still remain unbiased under heteroskedasticity. To test formally for heteroskedasticity we implemented Whites test and the results are illustrated again in Table 1. Based on the calculated p-value (0.53) that corresponds to Whites test, we fail to reject the null hypothesis of homoskedasticity. As a result our model seems to satisfy the assumption of homoskedasticity, implying that the performed statistical inference is correct. Our final concern is to e nsure that the residuals are normally distributed, which is one of the basic assumptions of the classical linear regression model. The assumption of the errors normality is considered essential for conducting correctly statistical inference. Finally, we tested for normality by making use of the Anderson-Darling statistic with the null hypothesis to be the presence of normality. The estimated Anderson-Darling statistic along with the associated p-value, for the residuals, is 0.85 and 0.44, respectively. It is clear that we fail to reject the null hypothesis of normality and therefore we have one more clue that our model is well specified. Question 4 As is clearly shown in question 3, the diagnostic testing performed for the statistical validity of the estimated model revealed the following a) the regressors are stationary, b) multicollinearity is not considered a threat, c) there is no serial correlation in the residuals, d) the residuals are homoskedastic and finally, e) the residuals are distributed normally. Therefore, we came to the conclusion that all the basic assumptions of the classical linear regression model hold and no further actions are required. Question 5 In this part of the coursework we augment equation (1) with the squares of the factor changes. The new specification is given by equation (2): (2) Parameter estimates for equation (2) along with their associated standard errors, t-statistics and p-values, are analytically illustrated in Table 3. The E-views command for the estimation of the above mentioned model is as follows: equation model2.ls exs_r_portofolio c exs_r_index g_term_spread g_fx g_brent (g_term_spread)^2 (g_fx)^2 (g_brent)^2 Examining the results in Table 3, we can say that from the three additionally included variables only one proves to be statistically significant (the GBPt2) at the 0.1 significance level (not 0.05 or 0.01). The significance and the magnitude for the non-squared regressors do not alter in any important way with respect to the corresponding results presented in Table 1. Additionally, the adjusted R-squared improved marginally from 0.839 to 0.848, implying that the additional regressors have contributed less than 1% in explaining the variability of the dependent variable. The diagnostic testing for equation (2), which is presented at the lower part of Table 3, reveals that the new model is well specified. In more detail, we realize that all the main assumptions of the classical linear regression model are adequately satisfied. There is no serial correlation, the residuals are homoskedastic and finally the residuals are distributed normally. Table 3. Estimation output for the augmented specification (equation 2) Variable Coefficient Std. error t-Statistic p-value constant 0.011998 0.003107 3.861951 0.0002 [ Rm-Rf ]t 1.037345 0.042858 24.20433 0.0000 GTSt 0.002770 0.003517 0.787418 0.4327 GFXt 0.039821 0.083831 0.475017 0.6357 GBPt -0.004681 0.024362 -0.192148 0.8480 (GTSt)2 -0.001131 0.000921 -1.229082 0.2216 (GFXt)2 -0.831541 1.931252 -0.430571 0.6676 (GBPt)2 -0.340632 0.184292 -1.848331 0.0672 Regression Diagnostic Statistics R-squared 0.857205 Mean dependent var -0.036483 Adjusted R-squared 0.848280 S.D. dependent var 0.057761 S.E. of regression 0.022499 Akaike info Criterion -4.686387 Log likelihood 289.1832 Schwarz criterion -4.500554 F-statistic 96.04850 Hannan-Quinn criter. -4.610919 Prob(F-statistic) 0.000000 Durbin-Watson stat. 1.843856 White hetero. Test 0.840402 LM test ser. cor. (2 lags) 0.546468 Whites test p-value 0.704900 LM test ser. cor. p-value 0.580600 Anderson-Darling nor. test 0.737227 LM test ser. cor. (8 lags) 0.615434 Anderson-Darling p-value 0.528500 LM test ser. cor. p-value 0.763100 In order to test whether the additionally included variables provide a better specification, we perform the Wald test for coefficient restrictions. The Wald test is applied to a ll the possible combinations that may arise among the three variables. The results of the Wald testing procedure along with their associated p-values are illustrated in Table 4. Table 4. Wald testing results Null hypothesis F-Statistic (p-value) 3.24 (0.02) 0.81 (0.44) 4.65 (0.00) 4.03 (0.02) When we tested the null of it was realised that we reject the null at the 0.05 level, suggesting that the three additional variables contribute significantly in explaining the dependent variable. In the case where the following is tested: we fail to reject the null at the 0.05 level, signifying therefore that the square of the oil inflation ( coefficient) is quite crucial. Moreover, in testing the restriction the null is rejected at the 0.01 level. Finally, when the restriction is tested we reject the null at the 0.05 level. Overall, the Wald testing procedure suggests that the preferred specification would be the one that excludes the square of the exchange rate percent age change. Therefore, the new adopted specification after the Wald testing procedure receives the form presented in equation (3): (3) Equation (3) is estimated with OLS and the results are illustrated in Table 5. The E-views command for the estimation of the model is the following: equation model3.ls exs_r_portofolio c exs_r_index g_term_spread g_fx g_brent (g_term_spread)^2 (g_brent)^2 Table 5. Estimation output for the specification of equation 3 Variable Coefficient Std. error t-Statistic p-value constant 0.011796 0.003060 3.854984 0.0002 [ Rm-Rf ]t 1.035900 0.042572 24.33292 0.0000 GTSt 0.002638 0.003491 0.755653 0.4514 GFXt 0.042275 0.083335 0.507297 0.6129 GBPt -0.004001 0.024223 -0.165184 0.8691 (GTSt)2 -0.001100 0.000914 -1.202750 0.2316 (GBPt)2 -0.392334 0.139300 -2.816473 0.0057 Regression Diagnostic Statistics R-squared 0.856968 Mean dependent var -0.036483 Adjusted R-squared 0.849374 S.D. dependent var 0.057761 S.E. of regression 0.022417 Akaike info Criterion -4.701399 Log likelihood 289.0840 Schwarz criterion -4.538796 F-statistic 112.8391 Hannan-Quinn criter. -4.635365 Prob(F-statistic) 0.000000 Durbin-Watson stat. 1.831355 White hetero. Test 1.066227 LM test ser. cor. (2 lags) 0.552305 Whites test p-value 0.396100 LM test ser. cor. p-value 0.577200 Anderson-Darling nor. test 0.690392 LM test ser. cor. (8 lags) 0.557522 Anderson-Darling p-value 0.566900 LM test ser. cor. p-value 0.810300 The econometric inference for equation (3), which is presented at the lower part in Table 5, reveals that again the selected model is well specified. There is no serial correlation, the residuals are homoskedastic and finally the residuals are distributed normally. The rationale for the inclusion of the i nitial variables squared lies in our intension to assess the presence of a non-linear impact that the independent variables may have on the dependent variable. The intuition in other words is that we actually generate a quadratic term. Consequently, if we have for example a positive coefficient for a variable and a negative coefficient for the square of the same variable, then it is implied that as the variable receives higher values the effect increases with a decreasing rate. Therefore, the interpretation of the coefficient for the (GTSt)2 variable is as follows: as the GTSt increases then the effect on the dependent variable decreases with the rate of 0.0011 (Table 5). The interpretation for the rest squared coefficients is quite similar. Question 6 The Chow breakpoint test is implemented for equation (3). The Chow breakpoint test is used to assess the stability of the estimated coefficients over a pre-specified breakpoint. The test depends heavily on the correct selection of the breakpoint. After the selection of the breakpoint the test is carried out by separating the initial sample into two sub-samples, with the first sample to be from the beginning of the sample up to the breakpoint and the second sample from the breakpoint up to the end. The main intuition of the test is based on the similarity of the sum of squared residuals resulting from the whole sample with the respective sum of squared residuals resulting from the equations that are fitted to each sub-sample. If there is a significant difference then this is indicative of a structural change in the coefficients derived from the whole sample regression. At this point we need to be very careful of the selection of the breakpoint. Based on the results presented abov e, and especially in question 1, we have realized that all the variables illustrated graphically show systematically a spike (extreme value) which takes place during the last quarter of 2008. The period indicated by the data coincides with the beginning of the global economic crisis. The beginning of the crisis is chronologically oriented by the collapse of the investment bank Lehman ÃÆ'Ã… ½Ãƒ ¢Ã¢â€š ¬Ã¢â€ž ¢rothers on September of 2008 (2008m09). Consequently, the choice of the 2008m09 as a break date for our application seems to be theoretically and empirically fully justified. The results of the Chow breakpoint test are presented in Table 6. The test is implemented for a break to all the estimated coefficients of the regression. As can be realized from the p-values of the three illustrated statistics we clearly reject in all cases the null hypothesis of no breaks at the 0.01 significance level. Table 6. Chow Breakpoint Test (equation 3) Null Hypothesis: No breaks at spe cified breakpoints Breakpoint: 2008:m9 Varying regressors: All equation variables Equation Sample: 2000:m10 2010:m09 F-statistic 3.226107 Prob. F(7,106) 0.0039 Log likelihood ratio 23.17603 Prob. Chi-Square(7) 0.0016 Wald Statistic 22.58275 Prob. Chi-Square(7) 0.0020 Clearly the confirmation of the structural change in the coefficients of the estimated regression reveals that our specification needs to be revised analogously in order to take into account the break. Such a re-specification may be the inclusion of a dummy variable for the period after the break date or otherwise cross products between the dummy and the independent variables in order to determine the magnitude of change for the initially estimated slopes. Question 7 In this section we will compare the three alternative specifications which have been presented (equations 1, 2 and 3) and estimated (Tables 1, 3 and 5) in the previous sections. For this reason we will make use of four different Statistics which are considered appropriate for the task at hand. These Statistics are the Adjusted R-square, the Akaike information criterion, The Schwartz criterion and finally the Hannan-Quinn criterion. For the adjusted R-square, this receives values between 0 and 1, the higher the value the better for the corresponding model. High values imply that high percentage of the dependents variable variability is explained by the regressors. For the three remaining Statistics, the lower the values they receive the better the model is. Table 7 below presents all these Statistics in order to select the final model. Table 7. Model selection criteria Statistic Model 1 Model 2 Model 3 Adjusted R-square 0.839409 0.848280 0.849374 Akaike -4.653130 -4.686387 -4.701399 Schwartz -4.536984 -4.500554 -4.538796 Hannan-Quinn criterion -4.605962 -4.610919 -4.635365 Based on the reported results in Table 7 it is immediately realized that model 2 is preferred in comparison to model 1 (higher adjusted R-square and lower values for the rest of the statistics) and model 3 is preferred in comparison to model 2 (also there is higher adjusted R-square and lower values for the rest of the statistics). Models 3 fit to the data is considered more than satisfactory as almost 85% of the variability that the dependent variable has is explained by the selected regressors. Question 8 Based on the model presented in Table 5 we will assess the results from a financial perspective. This task is mainly focused on the interpretation and the significance of the estimated coefficients. We have already proved that model 3 is well specified and as a result we may proceed to the analysis of the results. Regarding the expected theoretical sign of the regressors it can be stressed that the estimated signs do not deviate from those expected. The justification for the sign of each variable has been analytically presented in question 2 and the same rationale applies also to the finally selected specification. The most notable fact is that the market index, FTSE 100, excess returns was found to be significant at 99% confidence level. This implies that this factor is the single-most important factor in explaining our portfolios excess returns. Alternatively, the estimated coefficient of 1.035900 can be seen as a measure of risk for the portfolio constructed since it is infer red that if the markets excess returns increase by one unit then the portfolios excess returns will increase also by the value of the coefficient. Immediately we realise that our constructed portfolio is riskier than the market. This is because our portfolio is only a subset of the market portfolio and the market portfolio is more diversified and contains less individual risk. The constant can be interpreted as follows: if all the independent variables are simultaneously equal to zero then portfolios excess return is equal to 0.011796. The fact that the constant term is statistically different from zero suggests that our choice to use the APT model is correct provided that the CAPM model is a special case of the APT model. A non-significant constant term would favour the use of the CAPM model. Finally, the three included factors in the specification remain statistically insignificant implying that these factors do not contribute considerably in the explanation of our portfolios e xcess returns. There are probably other factors that may play a significant role in explaining our portfolios excess returns. Such factors, among others, may be the industrial production, money supply, inflation and markets capitalization. Their effect remains under further investigation.

Saturday, December 21, 2019

Essay on The Sport and Art of Dance - 881 Words

Many people play sports in their spare time. Some examples include football, basketball, and golf. But the surprisingly difficult sport of dance is commonly overlooked. Shanna LaFleur once said, â€Å"It takes an athlete to dance, but an artist to be a dancer.† Dance expresses strong feelings and emotions through graceful or sharp, powerful movement, revealing to the audience every bit of passion behind it. Countless forms of dance exist in the world. Jazz, ballet, and tap are the most common. When a person thinks of dance, they think of pink tights and tutus. Dance consists of so much more than that. Jazz, one of the most popular forms of dancing, usually consists of a more upbeat and fast tempo movement. The different types of jazz include:†¦show more content†¦Another dance form, known as contemporary, steals the hearts of most dancers and audience members. Most contemporary dances tell a story or convey a message. This style became known for combining different types of dance to form chorography that people could emotionally connect to. Lyrical, very similar to contemporary, embodies a more ballet look and feel. The slower motions and fluidity creates longer lines and to expresses stronger emotions. The movement, strongly based on the lyrics of the song, expresses a similar if not the same idea. Many people exclude dance in their mind when thinking about sports. The physical demands placed on the bodies of dancers prove to make them just as vulnerable as football players to injury. Just like any other physical activity, dance comes with a risk of injury. Injuries devastate many dancers’ careers. Luckily, reducing or avoiding them is a possibility. The practice of movements repeatedly that require extreme flexibility, strength, and endurance make them more likely to develop overuse injuries. Beginner dancers must take their time building their strength and flexibility slowly and carefully. Taking the time to properly warm up the major muscles of the body prevents dance injuries the most. John Wooden once said, â€Å"Don’t let what you cannot do interfere with what you can do. Dancing requires a great amount of muscle and flexibility and during theShow MoreRelatedIs Dance A Sport Or An Art?1489 Words   |  6 Pagesvery difficult sport, and a beautiful one beca use it is not about money. It s not like playing football or tennis - dance has no sponsors, it s just for the beauty. Maybe it is the only last pure sport,† states Carine Reitfeld, editor-in-chief of Vogue-Paris. Although not explicitly mentioned, Reitfeld is uncovering one of the dance industry’s largest debates: is dance a sport or an art? When asking this question one receives quite an ambiguous answer. Dance is more than just a sport, yet not purelyRead MoreDance Is An Expression Of Oneself Essay1422 Words   |  6 PagesPaper MLA. â€Å"Dance is an expression of oneself,† says many artists. There is the keyword: â€Å"artists†. Many ask, â€Å"Is dance a sport or an art?†. Is it? There has been much recent speculation on whether dance is a sport or an art. Dancers are athletes. Dancers endure much of the intense training that people who are considered athletes do. Dance is also a bodily way to express yourself meaning that it is an art. Dance can be seen from two very different spectrums: an art and a sport. Dance does fall intoRead MoreGoing Battle Of Art Vs. Sport : The Ballet World1335 Words   |  6 PagesOn-going battle of Art VS. Sport: The Ballet world Ballerinas are extremely competitive with each other and the ballet world has a hint of a barbarous culture. However, ballerinas are competitive with each other in the same way artists, musicians and actors are. Ballet itself is not a competitive sport; it is an art. In 2016, the International Olympic committee recently voted to restore wrestling to the Olympic games (Robb, Para 1). One activity that has never been brought to the committee’s attention:Read MoreDancers Deserves to Have The Titles of Athletes1247 Words   |  5 Pagesstrength† (dictionary). While dancing requires great artistry, artistry is just one aspect of dance, because there is clearly an athletic side as well. Dancers athletic side is not seen by many because of the reality of what is seen on stage, but is what is seen on stage all of it? The amount of passion and dedication dancers have leads to countless hours at the studio every week. With the many genres of dance to choose from, each involve athleticism one way or another. The many different options makeRead MoreDance : The Importance Of Dance As A Sport?1356 Words   |  6 PagesSport: an activity involving physical exertion and skill in which an individual or team competes against another or others for en tertainment. The amount of athleticism that is required for a dancer to posses is undeniably astonishing. On the other hand, some believe that dance is more of an art than a sport due to the thought that dance is a way of expression. Similar to football, the art of dancing engages an equal amount or more of extreme physical effort. Before all else, the athletic from ofRead MoreTechnicalities of Dance1710 Words   |  7 PagesBeaven 27 March 2013 Technicalities of Dance Dance is a universal language that involves exaggerated movements of the arms, legs, and body. With the sound of music, dance is more than just a form of expression. It is a moving portrait embraced by the curtain frame. It is a masterpiece assembled by artfully maneuvered strokes. The strokes don’t belong to that of the painter, but rather the educator who supervised the integration of music and dance. There it hangs on a stage like any other paintingRead MoreMen in Ballet: More than Meets the Eye Essay1296 Words   |  6 Pagesrealize how challenging and mind stretching this art is, especially when playing simple games such as charades: All that is acted out is a wimpy spin. Compared to other sports such as soccer, football, and basketball, it is just as and sometimes more difficult. Ballet is not merely an activity for girls; it is an art form that, by stretching the bodys mental and physical capacities, teaches discipline. During the Renaissance, the Italian dance master Domencio da Piacenza (1400-1470) copied downRead MoreAnalysis Of The Zuni Turkey Dance1119 Words   |  5 PagesThe Zuni Turkey Dance is an Native American Indian dance performed to entertain and to get people knowledgeable about their cultural heritage. It appeals to unfamiliar and familiar people. This dance appeals to an audience because it is a form of entertainment. Entertainment can be defined as a performance that pleases and audience. In the Zuni Turkey dance we can see the art of ;dancing, drums/musical instruments begin played ,costumes, and hymns.The performers are enthusiastic and full of energyRead MoreDancers Are The Athletes Of God1050 Words   |  5 Pagesoften used in the dance community to describe the mix of athleticism and spirituality with which dancers dance†(Bryant). There’s not much of a difference in jazz, modern, ballet, and hip hop dancing, just like there’s not much difference in socce r, basketball, baseball and football; both activities have their own purpose. A professional jazz dancer and a professional basketball player will both have their own reasoning as to why they play or dance the specific dance or specific sport but both will explainRead MoreThe Subculture Of Sports : A Little Girl990 Words   |  4 Pagesof art, strength and expression. Now being eighteen years old with about fourteen years of experience in the dance world, I have learned and developed the norms, values and practices of the culture, and the conflicting theory within it. Subcultures are â€Å"A set of distinctive values, norms, and practices within a larger culture.† (Brym and Lie 2012: 47). Dance in this case is placed under the subculture of sports; sports in many ways obtain special kinds of standards within the culture. Sports value

Friday, December 13, 2019

Can embryonic stem cells be used in the treatment of Parkinson’s disease Free Essays

Abstract: Current treatments of Parkinson’s disease (PD) remain symptomatic, for example Levadopa, and results in a number of negative side effects after a foreseen period of time. However, investigations into using human embryonic stem (ES) cells to generate dopaminergic neurons hold huge potential for future treatments. Results show several patients gain an increased percentage of dopaminergic neural mass in the substantia nigra following transplantations of neural cell grafts into the striatum. We will write a custom essay sample on Can embryonic stem cells be used in the treatment of Parkinson’s disease? or any similar topic only for you Order Now This suggests that grafts can work, although other studies show some patients fail to show improvements. There is also the risk of the formation of teratomas and teratocarcinomas in post-operative subjects, due to the self-renewal characteristics of the stem cells. Despite a number of studies proving that using human embryonic stem cells could be a reliable method of treatment, there are still a number of issues unresolved. Since the majority of experiments have taken place on primates, it is unreliable to assume that the same results would occur in human trials. There are also a number of ethical issues such as destroying the ‘potential human life’ of an embryo which, in several cases, is limiting the research and progression of new methods of treatment. Introduction Parkinson’s disease is a progressive degenerative disease of the substantia nigra, resulting in the depletion of dopamine in the striatum and the formation of protein bundles known as lewy bodies (1); such depletion of dopamine results in motor symptoms of which patients with PD present with, including resting tremor (2, 3). At present, the most common form of treatment for PD is Levadopa; however, it is only given once symptomatic and is thought that its effectiveness decreases over time (1). Investigations into the treatment of PD involving the use of embryonic stem cells to generate dopaminergic neurons for transplantation into the brain is currently in progress and this review is going to look at the prospects and issues that the use of human embryonic stem cells may bring about. (4). What are human embryonic stem cells? Human ES cells are unspecialised and can differentiate into a range of cells via cell division, in this case the most important being dopaminergic neurons (5). Human ES cells are generated from the pre-implantation stage of an embryo, a blastocyst, and can multiply rapidly, generating large numbers of cells (5, 6). This suggests there could be enough to provide sufficient amounts of DA neurons for clinical procedures. ES cells are taken from the eggs that have been fertilised in vitro, provided by consented donors (7, 8). How are human embryonic stem cells being used to generate dopaminergic neurons? ES cells are being used to produce tyrosine hydroxylase positive neurons by culturing, expansion and differentiation (fig 1). ES cell colonies are selected individually and grown in agar plates allowing for embryoid bodies to develop. Embryoid bodies are then further cultured in a medium containing Fibroblast Growth Factor-2 (FGF-2) for seven days. A number of cell masses in rosette formations (figure 2b), resembling neural tube structures, were observed within the embryoid bodies (6). Figure 1: Generating Dopaminergic neurons (12). Neural precursors showed expression of ‘nestin and musashi’, markers for neural progenitor cells (4): they act as a form of labelling identifying specific cells (9): Without FGF-2, no rosettes of orderly formation grew (6). When spherical neural masses formed after 14 days (figure 2a), it was noted that they could develop and multiply for over 120 days, providing evidence that there would be vast numbers of cells available for treatment (4).14 days is a short period of time tells us how efficient this method of neuron generation is. Figure 2: A – time in culture. B- ES cell colonies (10). One study (10) found that the number of tyrosine hydroxylase-positive cells generated by neural masses was very small (5.4% +/- 1.8%) and to increase these figures, looked at the effects of growth factors and how they altered differentiation in culture. When FGF2 and FGF20 were present, percentages of TH+ cells increased by 18.6%; however, neither growth factors alone had such an effect. Once cultured in a differentiation medium, neural masses showed physiological characteristics of neurons providing evidence that differentiation was in progress. (4). What evidence is there to suggest that human embryonic stem cells may be used as an alternative treatment for Parkinson’s disease? Several studies (4, 5, 11) quote that human ES cells are able to successfully produce dopaminergic neurons and decrease the symptoms of PD when grafted into the brain. One study (10) experimented on a primate model with an induced form of PD and investigated as to whether the isolated TH+ neurons were able to function as dopaminergic neurons. The neurospheres grown from ES cells were grafted into the putamen of monkeys, only of which started to show signs of PD and whose conditions had deteriorated beyond a period of 12 weeks. After transplantation, the behaviour of the primates was observed and analysed using MRI scanning. 10 weeks following, neurological scores of the primates increased significantly in comparison to the control models. Having a control enables a clearer analysis to take place, and distinguish definite improvements in the primates’ behaviours. A similar investigation (11) performed bilateral implants on 61 patients into the putamen. When looking at fluorodopa PET scans 12 months post-surgery, 85% of patients presented with neural mass growth and showed physiological improvements. However, one study (9) suggests that the outcome for each individual is not certain to gain the same result, because processes such as apoptosis are unable to be controlled, resulting in cell death within days after transplantation: this presents in scans as a lack of fluorodopa uptake, suggesting a range of cell survival. It is thought that if treated with neurotrophic factors before surgery, it could improve cell survival (11). Comparing the two studies (10, 11), both results showed promising improvements, emphasising that although one study (10) was on primates, and the second (11) involved humans, both experiments gained a similar positive result. However, this point could be argued as the primate was induced with PD rather than developing the progressive disease naturally. Analysis of more than one trial (11, 12) has indicated that the response to transplantation could show a positive correlation alongside the patients’ ability to successfully react to L-dopa prior to the operation, as well as the patients’ stage of disease. One study (12) presented that if a patient scored lower that 50 on the unified Parkinson’s scale before surgery, then they were more likely to gain a positive result from the transplant. Some may say that for the treatment to be appreciated, it shouldn’t matter what stage the patient is at when receiving the transplant, and that it should work at all stages of the disease, although as proven with diseases such as cancer, this is not always possible. As well as increased F-dopa uptake, a studies on animals (13, 14) observed rotational behaviour in response to amphetamine before and after surgery. Results showed a decrease in the scores of the animals given the graft, whilst sham controls showed no improvement (figure 3). One study (13) was repeated on 4 occasions across a 9 week period and continued to show gradual reduction. This provides evidence that the graft was beginning to improve dopaminergic neuron function, as motor functions were showing significant improvements (14). Figure 3: Rotational behaviour scores (13) Another study (12) says that neurons generated from the cells of early aborted embryos are able to survive when transplanted into the striatum and recover the loss of function by 10-40%, by restoring dopamine production in the grafted area (15). However, such results may be unreliable in respect to human transplants as these studies were performed on rats and monkeys, of which the disease was induced by creating selective lesions. Such lesions are, therefore, in a different condition compared to natural lesions found in the brain of a patient with progressive PD (9). Transplants are thought to have decreased the occurrence of dyskinesias, a side-effect of levodopa; however, this has mostly only been proven in rats and monkeys. In addition, a number of patients have been able to stop using levodopa completely, although this is not a regular occurrence. On the contrary, a number of subjects have been noted having developed off dyskinesias: 7-15% of grafted patients (5). It is thought that this is down to the fact that the neurons are unable to function properly; this could be due to the overproduction of dopamine in the striatum (12). If there are consequences after transplantation, of the same severity as previous to the transplant, is it worth performing the operation? How are the generated neurons transplanted into the patientWhat are the issues with this? Grafts are injected into the brain whilst under anesthesia (16) and, as with all surgery, poses risks such as haemorrhage and infection (15). To minimise this, the number of needle passes is kept to a minimum. This was demonstrated in more than one case (9, 11, 15) where the needles were passed through the front of the head, through to the putamen bilaterally using a total of 4 needles (figure 4). In one study (16), 8 needle passes were used, however, this had no detriment to the outcome of the transplants, both achieving regeneration. ES cells themselves also pose risks. With characteristics such as pluripotency and self-renewal, stem cells have the potential to form teritomas and teratocarcinomas which, at present, is one of the greatest risks; without knowing that they won’t form, transplatation of human ES cells will cease to be promising (17). Figure 4: MRI and PET scans showing F-DOPA uptake and needle passes (8). In order for this method to be successful, such characteristics of the cells need to be able to be controlled, and by doing so, will reduce the likelihood of teramtomas forming. Nonetheless, human ES cells maintain a normal karyotype and, therefore, these growths are not thought to be of the malignant variety (5). Despite this, there is evidence to suggest that teratomas formed from the transplantation of early or unspecified neurons into the brain, can lead to incomplete motor benefit in models of PD (18). In the majority of studies, patients were given immunosuppressive therapy before surgery to prevent rejection. The drug Cyclosporin was given, however, the course of the treatment varied, fluctuating between 2 days to 2 weeks (8, 11, 19). In such cases, when the immunosuppressive medication was withdrawn post-operatively, there was no evidence of reduction in f-dopa uptake, suggesting that the graft was functioning properly (19). One study (9) claims that immunosuppressive treatment is not needed when the graft is kept within the same species. What ethical issues are there with using human embryonic stem cells? One question that will continue to be brought up in regards to embryos is ‘at what stage is the embryo a human life?’ One book (20)suggests that for research on an embryo to commence, informed consent must be given as many people believe that the blastocyst has the potential to be a human being. However, because an embryo is incompetent of doing so, then the research cannot take place and, if it did, then it is thought that it would be restricting the embryos right or potential to life. Despite this, the use of stem cells derived from blastocysts continues to take place (20).Opinions vary and many of those who object to the use of embryos are subject to religious views: it is not necessarily a personal opinion but a matter of principle as to who has the right to determine life or death. One way of presenting the idea of using ES cells to those ethically opposed is by carrying out a benefit to risk ratio, weighing up the pros and cons of the situation. One argument (21) emphasises potential relief of symptoms, and the withdrawal of pharmacological treatment. It could not only benefit the subject, but also influence those affected indirectly by PD. Opposing to this are the risks of tumour formations and infection both during and after surgery, along with rejection by the immune system. With ethical issues in mind, Parthenogenesis has provided an alternative way of deriving pluripotent stem cells without damaging embryos, preventing the destruction of potential life. Asexual reproduction of sex cells could be the route to generating vast amounts of pluripotent stem cells appropriate for transplantation, without the ethical issues that we face today (18). Discussion: Looking at the evidence provided, it is viable to conclude that the use of human ES cells to produce dopaminergic neurons for transplantation into the brain has potential for future treatments. However, at present, studies are unable to provide valid evidence that this alternative treatment is guaranteed to work on a world-wide basis, as there is yet to be a steady correlation of improved brain function post-operative. Alongside this, there will continue to be a number of ethical arguments against the idea with respect to using human embryos as the source of stem cells, although, as discussed previously, other methods of generating stem cells such as parthenogenesis could be the answer to this. A greater knowledge of how the cells are differentiating and having the ability to gain control of this would provide a much better prospect for the future pioneers of embryonic dopamine cell transplantation. With greater research and more promising results, the use of human ES cells to genera te dopaminergic neurons could provide an effective method of treatment in the near future, which could lead to the successful restoration of normal brain function. References: (1) Schapira, A.V.H., 1991. Parkinson’s Disease. Science, Medicine and the future, 318, pp.311-314 (2) Chinta, S.J., Andersen, J.K., 2005. Cell focus in Dopaminergic Neurons. The International Journal of Biochemistry Cell Biology, 37, pp. 942–946 (3) Zigmond, M.J., Burke, R.E., Pathophysiology of Parkinson’s disease. Neurpharmacology: the fifth generation of progress, 123, pp.1782 (4) Soo Cho, M., Lee, Y.E., Kim, J.Y., Chung, S., Cho, Y.H., Kim, D.S., Kang, S.M., Lee, H., Kim, M.H., Kim, J.H., Leem, J.W., Oh, S.K., Choi, Y.M., Hwang, D.Y., Chang, J.W., Kim, D.W., 2008. High Efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells. PNAS, 105, pp3392-3397 (5) Wainwright, S.P., 2005. Can stem cells cure Parkinson’s disaeaseEmbryonic steps toward a regenerative brain medicine. British Journal of Neuroscience nursing, 1(3), pp.110-115 (6) Zhang, S.C., Wernig, M., Duncan, I.D., Brustle, O., Thomson, J.A., 2001. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nature, 19 (8) Mendez, I., Sanchez-Pernaute, R., Cooper, O., Vinuela, A., Ferrari, D., Bjorklund, L., Dagher, A., Isacson, O., 2005. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson’s disease. Brain, 128, pp. 1498-1510 (9) Bjorklund, A,. Dunnett, S.B., Brundin, P., Stoessl, A.J., Freed, C.R., Breeze, R.E., Levivier, M., Peschanski, M., Studer, L., Barker, R., 2003. Neural transplantation for the treatment of Parkinson’s disease. The Lancet Neurology, 2, pp.437-445 (10) Takagi, Y., Takahashi, J., Saiki, H., Morizane, A., Hayashi, T., Kishi, Y., Fukuda, H., Okamoto, Y., Koyanagi, M., Ideguchi, M., Hayshi, H., Imazoto, T., Kawasaka, H., Suemori, H., Omachi, S., Iida, H., Itoh, N., Nakatsuji, N., Sasai, Y., Hashimoto, N., 2005. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. The Journal of Clinical Investigation, 115(1), pp.102-109 (11) Freed, C.R., Leehey, M.A., Zawada, M., Bjugstad, K., Thompson, L., Breeze, R.E., 2003. Do patients with Parkinson’s disease benefit from embryonic dopamine cell transplantationJ Neurol, 3, pp.44-46 (12) Isacson, O., 2003. The production and use of cells as therapeutic agents in neurodegenerative disease. The Lancet Neurology, 2, pp.417-424 (13) Bjorklund, L.M., Sanchez-Pernaute, R,. Chung, S., Anderson, T., Yin Ching Chen, I., McNaught, K.S.P, Brownell, A.L., Jenkins, B.G., Wahlestedt, C., Kim, K.S., Isacson, O., 2002. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. PNAS, 99 (4), pp.2344-2349 (14) Kim, J.H., Auerbach, J.M., Rodriguez-Gomez, J.A., Velasco, I., Gavin, D., Lumelsky, N., Lee, S.H., Nguyen, J., Sanchez-Pernaute, R., Bankiewicz, K., McKay, R., 2002. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson’s disease. Nature, 418, pp.50-56 (15) Freed, C.R., Greene, P.E., Breeze, R.E, Tsai, W.Y., DuMouchel, W., Kao, R., Dillon, S., Winfield, H., Culver, S., Trojanowski, J.Q., Eidelberg, D., Fahn, S., 2001. Transplantation of Embryonic dopamine neurons for severe Parkinson’s disease. The New England Journal of Medicine, 344 (10), pp.710-719 (16) Olanow, C.W., Goetz, C.G., Kordower, J.H., Stoessl, A.J., Sossi, V., Brin, M.F., Shannon, K.M., Nauert, M., Perl, D.P., Godbold, J., Freeman, T.B., 2003. Double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson’s disease. Ann Neurol, 54, pp.403-414 (17) Wu, D.C., Boyd, A.S., Wood, K.J., 2007. Embryonic stem cell transplantation: potential applicability in cell replacement therapy and regenerative medicine. Frontiers in Bioscience, 12, pp.4525-4535 (18) Sanchez-Pernaute, R., Lee, H., Patterson, M., Reske-Nielsen, C., Toshizaki, T., Sonntag, K.C., Studer, L., Isacson, O.,2008. Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson’s disease. Brain, 131, pp.2127-2139 (19) Piccini, P., Pavese, N., Hagell, P., Remier, J., Bjorklund, A., Oertel, W.H., Quinn, N.P., Brooks, D.J., Lindvall, O., 2005. Factors affecting the clinical outcome after neural transplantation in Parkinson’s disease. Brain, 128, pp.2977-2986 (20) Cusine, D.J., 1991. Experimentation: some legal aspects. Experiments on Embryos, (editors Anthony, D. Harris, J) pp.120. Routledge: London (21) Master, Z., McLeod, M., Mendez, I,. 2007. Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson’s disease. Journal of Medical Ethics, 33, pp.169-173 Web References: (7) National Institute of Health. Stem Cell Basics. [online] Available at: [Accessed 9th March 2011]. Figure References: Title page: Available at: [Accessed 21st March 2011] Figure 1 (12) – Isacson, O., 2003. The production and use of cells as therapeutic agents in neurodegenerative disease. The Lancet Neurology, 2, pp.417-424 Figure 2 (10) – Takagi, Y., Takahashi, J., Saiki, H., Morizane, A., Hayashi, T., Kishi, Y., Fukuda, H., Okamoto, Y., Koyanagi, M., Ideguchi, M., Hayshi, H., Imazoto, T., Kawasaka, H., Suemori, H., Omachi, S., Iida, H., Itoh, N., Nakatsuji, N., Sasai, Y., Hashimoto, N., 2005. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. The Journal of Clinical Investigation, 115(1), pp.102-109 Figure 3 (13) – Bjorklund, L.M., Sanchez-Pernaute, R,. Chung, S., Anderson, T., Yin Ching Chen, I., McNaught, K.S.P, Brownell, A.L., Jenkins, B.G., Wahlestedt, C., Kim, K.S., Isacson, O., 2002. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. PNAS, 99 (4), pp.2344-2349 Figure 4 (8) – Mendez, I., Sanchez-Pernaute, R., Cooper, O., Vinuela, A., Ferrari, D., Bjorklund, L., Dagher, A., Isacson, O., 2005. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson’s disease. Brain, 128, pp. 1498-1510 How to cite Can embryonic stem cells be used in the treatment of Parkinson’s disease?, Essay examples

Thursday, December 5, 2019

Children Brain Disability and The Risk of Heart Diseases

Question: 1. Inadequate amounts of omega 3 can be a reason to children brain disability such as attention deficit disorder. 2. Obesity can increase the risk of heart diseases, brain disorder, and kidney damage and defect the immune system. Answer: 1) Inadequate amounts of omega 3 can be a reason to children brain disability such as attention deficit disorder. Attention deficit hypersensitivity disorder (ACDH) is most common disorder in school age children. ACDH is a developmental disorder which is characterised by inappropriate development, inadequate attention, impulsivity and hyperactivity in children. Omega -3 fatty acid is an alternative medication for ACDH. Both omega-3 6 are essential for human and cannot be synthesized in the body, so they are provided by the diet. The longer chain, highly unsaturated fatty acid (HUFA), of each series, omega-6 (alpha- arachidonic acid) and omega-3 that is eicosapentaenoic acid (EFA) and docosahexaenoic acid (DHA) are important for development of brain. Studies were carried out to determine the efficacy of omega-3 or n-3 HUFA in ADHD symptoms. For this, SWAN and conners questionnaires were used to access change in ADHD symptoms. 26 children were divided into two groups and participated in 16 weeks study. In first phase, group A administered with n-3 HUFA and group B received n-6 HUFA as placebo. In second phase group B received n-3 HUFA and group A received same n-3 HUFA. Analysis of the teacher completed SWAN questionnaire revealed, no significant difference in ADHD symptoms whereas parent version based on conners questionnaire showed significant improvement in ADHD symptoms like impulsivity and inattention during first phase. In phase2, group B showed more improvement as compared to group A. In fat analysis, n-3 HUFA family (EFA and DHA ratio) levels increased and ALA to EFA ratio declined in first phase (table no. 1). In second phase, no significant change occur in levels of EFA and DHA, whereas increase in level of ALA to EFA ra tio (table no.2). Table no. 1 Table no.2 The results of study showed that omega-3 should be given in dietary supplements which helps in maintaining symptoms related to children brain disability such as attention deficit hypersensitivity disorder. Duration of supplementation should also be considered as in many studies, better results were observed with longer supplements administration. Reference Blanger S. A. et al., Omega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled study, Paediatr Child Health, vol.14, no. 2, pp. 89-98, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661342/. 2) Obesity can increase the risk of heart diseases, brain disorder, and kidney damage and defect the immune system. In todays life style, obesity is common problem. Obesity is a condition caused by an accumulation of excess body fat. It is measured by Body mass index. Overweight or obesity caused many problems related to health. It causes heart problems like coronary heart disease, kidney problem like type-2 diabetes, brain disorders and weak immune system. Renin angiotensin system (RAS) have important role in regulation of blood pressure, fluid and electrolyte balance. In recent study, RAS is linked with brain, heart, kidney, and adipose tissue. As RAS was found to be increased during obesity. During clinical trials, anti hypertensive effects was shown by inhibition of RAS which also provide protection against development of type-2 diabetes. In animal model with targeted inactivation of RAS gene showed improved insulin resistance. Obese patient whose weight problem is associated with uncontrolled carbohydrate intake is linked up with atypical depression. Carbohydrate intake causes release of serotonin in the brain, which has anti depression effect. Combined weight loss (less calorie diet, physical exercise, no fast food) and agents that deactivate RAS (ACE inhibitors and angiotensin II receptors antagonist) are best option to fight disorders which are caused by obesity such as heart, kidney, brain and weakening immune system. Reference Praga M., 2002, Obesitya neglected culprit in renal disease, Nephrology Dialysis Transplantation, vol. 7, no. 7, pp. 1157-1159, doi: 10.1093/ndt/17.7.1157. Kollias H., Research Review: High-protein diets safe for kidneys, https://www.precisionnutrition.com/high-protein-safe-for-kidneys.

Thursday, November 28, 2019

Judge`s Wife By Allende Essays - Frankenstein, Victor Frankenstein

Judge`s Wife By Allende In "The Judge's Wife" the author, Isabel Allende, uses a variety of techniques to make full use of the limited space within her short story. By using strong imagery, providing a background, providing believable human actions, and examining justice, M. Allende creates a piece readers can understand to the point of empathy. Because her short story examines human behavior in respect to passions, justice, and emotion (love) in a plausible manner one can find close similarities between her work and that of Mary Shelly's Frankenstein. The author makes use of imagery to embellish not only upon her environment, but also her characters. M. Allende presents the ideas of corruption, innocence, and strictness simply through well-selected adjectives that lend eloquently to the descriptions of her characters. The strait laced judge being "...dressed formally in black ... and his boots always shone with bees wax " (Allende, 422). One can infer by details such as those that that particular individual appreciates formality, and considering his desert location, a strict adherence to it. The author also uses images of deformity demonstrate the corruption of her main character, Nicholas Vidal; by providing him with four (4) nipples and a scared face the reader can have a visual representation of the character's tragic formation. In much the same manner, one can see such development within Frankenstein's creation. The monster's grotesque outward appearance reflects his corrupted creation. Using such imagery the author allows the readers to form a solid conception of the plight of their characters. Mary Shelly uses lovely poetic imagery in much the same way to define, and give three-dimensional presence to her characters. Such use of imagery for the purpose of character definition can most clearly be seen in her description of her monster: "His limbs were in proportion, and I had selected his features as beautiful. Beautiful, Great GOD! His yellow skin scarcely covered the work of muscles and arteries beneath; his hair was of a lustrous black and flowering; his teeth pearly whiteness; but these luxuriances only formed a more horrid contrast with his watery eyes, that seemed almost of the same colour as the dunwhite sockets in which they were set, his shriveled complexion and strait black lips." (Shelly, 56) In viewing the above passage, much of the same type of character definition can be seen; very similar to the manner in which Allende casts her deformed mold of her creature, Nicholas. Beyond merely presenting imagery to enhance the characters, the Allende also supplies background information in order to enhance the readers understanding of how the main character arrived at his current state. The author focuses on the main character's fatherless and loveless conception in order to accentuate how his development occurred. In a similar fashion Allende's character Nicholas Vidal was conceived in a similar fashion as Frankenstein's monster. Both are created and ultimately rejected by their creators who attempt to destroy them. These horrid monsters are invariably unwanted by their creators, thus their creators go to great lengths to attempt to snuff out the lives of the creations in order that they not wreak havoc upon the world. Both authors using this particular method of rejection to temper the souls of their monsters to the hardness of iron (Allende, 423). In each case this extreme form of temperament creates an almost supernatural being, filled with great destructive forces. Further extending upon the parallel roles of Nicholas and the Monster, a clear outcasting from society also aids in their murderous temperament. Each character finds himself rejected by society. The monster, from Frankenstein, is rejected by the family he assists solely due to his grotesque appearance. In much the same way Nicholas is assumed early on in his life by "decent folk" to become a criminal due to the telling marks on his face. It may well be said that though the Judge, in his strait laced figure, may not have directly created Nicholas, yet in reality he probably did in deed, like the rest of society, stereotyped and eventually outcast Nicholas based solely upon the scars on his face. In each case the author makes use of societies tendency to categorize and reject an individual based solely on their exterior shells, rather than probing the unique individual. To solely focus upon the main character within this story would be folly when making a true comparison to Frankenstein. Indeed the role of the judge has many overlapping qualities with Victor Frankenstein. Each man peruses, as both texts put it, their own "creature", to the points of virtual insanity. In doing

Sunday, November 24, 2019

CHEROKEE INDIAN TRIBE essays

CHEROKEE INDIAN TRIBE essays The Cherokee Indians first lived in Tennessee. The name Indian first came from Christopher Columbus, who thought that America was part of the Indies, Asia. The first person to come across Indians was Hernando de Soto, in 1540. In wintertime the Indian men wore long sleeved shirts, loose fitting leggings, and moosehide moccasins. Women wore skin dresses tied at the waist and long, fitted leggings. Indians would hunt deer, elk, moose and buffalo. They would also eat rabbits, raccoons and birds. The women would sometimes make a stew with the meat. They also ate berries, nuts, fruit and beans and corn. Indian houses were made of stone, wood, skins, twigs and mud. There were wigwams; tipis, earth and grass covered houses. The tipis were made of buffalo skins. The tipi would protect the Indians from the cold winters. They always faced the tipi towards the east because the winds came from the west. The Indian children liked to have toys, their fathers and grandfathers would make small bows and arrows, sling shots and bean shooters. The girls liked to string berries to make a necklace; they made dolls out of grass, pine needles and bark. The boys would practice target shooting when they were old enough to prepare for when they would hunt. The Indians worshipped the sun, the wind and the rain. They celebrated places on earth that were important to the Indian people, such as a mountain, a lake or a valley. The Indians believed animals including birds were also people, just like the tribes. Indians knew a great deal about nature, they believed that a job was well done only when the spirits had been thanked. They had dances and festivals to help make their crops grow. Sequoyah was a great Cherokee Indian. Sequoyah was born in 1776 at a village called Tuskeegee. He was the first man to create a writing system for the Cherokees. Sequoyah never learned the English alphabet so he began to make up symbols th...

Thursday, November 21, 2019

Finance assignment Example | Topics and Well Written Essays - 1250 words

Finance - Assignment Example These Advisory services provide the clients to grow. A Financer: as a financer it provides their clients i.e. the local, state and national governments to finance and expand the infrastructure. It also works for the clients to transact, support, manage, innovate and invest (The Goldman Sachs Group, Inc. (GS), 2015). The profit on the investments is known as the rate of return, it can be of two types. Firstly are the Dividends that paid to the shareholders out of the profits of the organization in the form of returns of the investments made by the shareholders. The dividend rate is announced by the Board of Directors of the organization. Secondly, the return is in the form of Capital Gain/Loss. Mostly, the capital gain is reinvested by the shareholders to get new shares of the company. The total return can be calculated by adding the Dividends and the Capital Gain. Where Rs denotes the rate of return from investment in the company’s shares, DY denotes the dividend yield that provides investors the idea about the actual percentage of returns paid out to the shareholders in the form of dividends, and CG is the capital gain that shareholders can achieve from their holding in the company’s shares. The dividend yield can be calculated using the following formula. Where, D1 is the dividend expected in period 1 that is determined by applying an estimated growth rate of dividends to the dividend paid in period 0, P0 refers to the price of the company’s shares in period 0 and P1 is the stock price in period 1. It helps in measuring the risk of change in the value of the company’s stock in relation to the change in the value of the market index. It is mainly used to compare the risk of one stock with other stocks. The measure can help investors make their investment decisions based on their risk assessment and acceptance of risk. The value of beta equal to 1 represents that

Wednesday, November 20, 2019

Critical Analysis of Globalisation Implications on HRM and Future Essay

Critical Analysis of Globalisation Implications on HRM and Future Challenges for People Management within Organisational Setting - Essay Example , this has resulted into unprecedented results such as increased competitiveness among private and public sectors in numerous countries around the world. There are significant measures that are taken by human resource managers to gather information regarding development strategies that are vital in human resource management. Therefore, in different organizations around, human resource departments are focusing on implementing strategies that facilitate transformation of business in order to cope with modern challenges and exploit opportunities in the business environment (Belcourt & McBey, 2010 6). Globalisation has facilitated significant transformation of human resource; in this case, businesses can connect to new places around the world, and managers can make decisions that are supported by information gathered from different parts of the world. In addition, globalisation is widening talents through development of pools comprising of marginal, permanent or fluid employees. Globalis ation has also promoted processes of establishing a market oriented development strategy, thereby creating more opportunities to world’s economy. In this case, the world has been converted in to a single interdependent global market place, which is attributed to increasing competition and economic change; in fact, these changes have a significant degree of unpredictability (Ozbilgin, 2005, 45). Competitiveness has been established on a state or enterprises level, where value is added to global economic products, services and process that involve human resources. Therefore, this competition calls for knowledge and skills, which are offered by human resources in organizations. Furthermore, knowledge and skills are crucial elements of a workforce, and they have become sources of competitive... This essay stresses that organizations are expected to comply with all rule and regulations formulated by the government. In this way, theses organizations can avoid facing challenges resulting from changes in legal and political environment. Different organizations around the world are competing with an aim of attaining good public image that can result high profitability. Therefore, considering challenges that have been identified, HR managers are expected to take responsibility of training workers on ways to offer quality products and services to customers. Through this way, organizations can generate sufficient profits that can support them during economic recessions. The paper has conducted a critical analysis of globalisation implications on human resource management, and it has identified and discussed future challenges that are likely to be faced by HR managers within organization setting. The paper began with introduction section that gave an overview of globalisation and future challenges of human resource management. The other section covered a critical analysis of impact of globalisation on the HR management. In this section, the paper outlined and discussed in great lengths, factors that has promoted globalisation in human resource field. Finally, the last section explored future challenges that are likely to be faced by human resource managers, thereby identifying remedies to solve these challenges.

Monday, November 18, 2019

Anatomy of a Family Law Case Research Paper Example | Topics and Well Written Essays - 750 words

Anatomy of a Family Law Case - Research Paper Example The status of each member chances when the couple enters into the marriage agreement (Folberg, & Milne, 2000). For instance, the man becomes a husband and the woman becomes a wife. It gives the husband new responsibilities and rights as well as the woman. Legally, a marriage is greatly honored since it is perceived to be the basis of the family. Traditionalists view a marriage as the as the starting point of preserving moral status in the community. It is in the view of traditional ethics that in a marriage, the husband provides support of the family by providing the necessary requirements like food, clothing, and shelter among other essentials. On the other hand, the wife has the obligation of serving her husband and the family at large. She has the duty to take care of the children, maintaining the house, living in the home and engaging in sexual activities with her husband. The current law has tried to modify traditional functions of the married people since many women have joined the working forces in large numbers. Husbands on the other hand engage in taking care of children and taking care of their homes while their wives are at work. Any individual who may require making alterations in the marriage agreement must do it in accordance with the law. ... The laws protect all marriages whether the couple may be interested or not. Legal rights and benefits of a married couple There are several benefits and rights that one gets when they are married. The society treats the couple as a grown up and one can get priorities while making medical resolutions and receive assistance on behalf of the other family member. It includes rights that may need attorney and other related legal requirements. Social security, medical and disability benefits can be paid to a spouse as well as military and veteran benefits. All employers usually include spouses of their employees to insurance plans, a service that unmarried people cannot receive. The employers also provide bereavement leave for married people to attend funeral programs of their members and allow a spouse to care for the other during illness. Marriage gives a partner the right to visit a spouse in jail or in hospital and sue somebody on behalf of him or her (Ahrons, 2004). Spouses that divor ce are entitled to sharing of the property of the community according to legal requirement of most of the nations. In case of death of one spouse, the other spouse is entitled to organize funeral preparations without intimidation of any form. The married couple is allowed to file a joint tax return and get the ability to organize for partnership to raise capital for business operations (Bohannan, 2005). Ending a Marriage According to the Law of California any individual who wish to file a divorce or separation must reside from a different residence from his or her partner for one full year before the process begins. It gives the spouses an opportunity to reconsider their stands before annulment. The annulment determines that the marriage did not

Friday, November 15, 2019

Prejudice and racism

Prejudice and racism How do the writers Nadine Gordimer and Mildred Taylor explore prejudice and racism in different cultures? Both writers explore racism and prejudice in their books, but you can spot racism and prejudice in one book much quicker. Both writers show how racism affects not only black people but also the whole of society and your family. Both stories are set in different locations and have different affects on the people and society. Racism is shown in different ways in both stories. â€Å"Country Lovers† is set in South Africa, during the time of apartheid. â€Å"The Gold Cadillac† is set in North America and a black family goes down to South America and face a new experience. The new experience they face is racism and it affects the family in many ways. â€Å"Country Lovers† is written by Nadine Gordimer, it is written in 3rd person, while â€Å"Gold Cadillac† is written in 1st person. Both view points are effective. The 3rd person view point shows us an unbiased and direct view of what is happening, without any interference. The 1st person view point in â€Å"The Gold Cadillac† is also very affective as you are seeing out of the eyes of a young child, whom doesnt understand racism and its affects. We see quite clearly the reaction of the little girl when she doesnt understand what is being said. In â€Å"Country Lovers†, the black children play together with the white children, at a very young age. This is because the pressure of racism in the society doesnt influence small children as they are still young. However, when the white children go to school ‘they soon dont play together anymore. This shows us that racism is already starting to spread even though the children have only started to go to school now. This is due to the fact that the society is evolving around these children and the ‘vocabulary of boarding school has brain-washed them into believing that white people are the masters and black people are the servants. The black children start calling their former playmates ‘missus and baasie this is described as an ‘easy transition but surely it cant be due to the fact that their body is changing as well as their minds. Black children are turning into teenagers and they feel that calling their former playmates ‘missus and baasie is a normal transformation for every black person. In â€Å"The Gold Cadillac† on the other hand we can acknowledge the fact that not all black people are inferior to white people. Racism is better concealed in â€Å"The Gold Cadillac†. We dont know if the family is black or not until we reach line 166, where ‘Lois father says he wants to go down to Mississippi with the ‘fine car. Mr. Pondexter says ‘Not much those folks hate moren to see a northern Negro coming down the in a fine car. Although, the text only reveals the fact that they are black but we have been given clues on the speech and dialect by ‘Lois. Wilbert doesnt change his mind even though he was told it was too dangerous for a black man to go down South even though he was told they would ‘lynch you. The word ‘lynch sent a shiver through ‘Lois and her sister even though they dont know about racism. By this we can see how racism in the north has not affected the two black girls at all. The educational system started with both white and black children in primary education where they spoke local dialect and then after that the white children went to secondary education, where they learnt Standard English and the black children went to work, on farms of the white people, and they learnt the language of authority and how to obey it. Immorality Act 1950 1985 was one of the first Apartheid laws in South Africa. It attempted to forbid all sexual relations between whites and non-whites. In 1949, interracial marriages had been banned by the Prohibition of Mixed Marriages Act. This law is to separate black and white. This caused trouble for Paulus Eysendyck and Thebedi (two main characters in this story) as they were secretly in a relationship between a white boy and black girl (which was against the Immorality Act). ‘She had to get away before the house servants who knew her, came in at dawn. This shows the compassion and determination to keep their relationship ongoing. The only relationship that can be between blacks and whites is servant and master, no other relationship is permitted under the legal laws of South Africa. Families have to stick together and also stick together with friends. In â€Å"The Gold Cadillac†, the dad of ‘Lois decided to go all alone to Mississippi but was then persuaded to go down there all together, so that they were stronger to tackle racism and prejudice believes and views. A group of people are mentally and physically stronger than one person all alone and with no one to back him/her up with. They were leaving to go down South to Mississippi. In the second paragraph of â€Å"Country Lovers† it said ‘The first holiday after he had gone to boarding school he brought home for Thebedi a painted box he had made in his wood work class. Here we can see how he developed their relationship even though they havent been in contact for a while. He couldnt give the box directly to Thebedi because ‘he had nothing for the other children in the kraal. Thebedi is shown to be inferior to Paulus, ‘He told her, each time when they would meet again. This clearly shows that Paulus has all the power in the relationship and that is controlling the inferior Thebedi. Thebedi doesnt say a single word; this shows the effect or racism and how racism and authority made them believe they were servants had set into their minds and also that they had no control of whether or not to do what is being told. To me in this part of the story it just seems like an affair not like love at all. The family enters South America and they soon start noticing sign like ‘WHITE ONLY, COLOURED NOT ALLOWED. This distracts ‘Lois and she doesnt understand what these signs meant or why they were there. They began to see South America in a different view, the racist view. In â€Å"Country Lover†, Paulus and Thebedi meet on a very hot day at the river bed side. They just sit there at first without talking or anything. Paulus seems to be evolving around the beautiful nature. Nadine Gordimer portrays their meeting and sex as a natural occurrence when she puts it alongside such a beautiful environment, next to the water flow. This just gives us a sense of reality and the richness of this love is seen. ‘he was surprised and she was surprised by it too, they didnt know it could be so lovely and the nature just seems to evolve around both of them. Nadine Gordimer is making a direct remark against the prejudice that black people are ugly and white being the only beautiful colour. This scene also shows the immodesty of the white girls as they are seen in ‘bikinis but Thebedi is shown as ‘her dress bunched modestly. This shows how modest Thebedi is and that she doesnt want to be tricked into believing things to quickly. She is looking o ut for herself. Nadine Gordimer compares this to the cheap plastic relationship they had had in Paulus house when ‘the Mercedes drove away. She portrays as it is much better to have a relationship in the nature. A police car comes and stops the Wilbert family in the Southern States and he ‘eyeballs the car. The police officer call Mr. Wilbert ‘boy which you can see is prejudice as he is already looking down at him. Without asking any questions, the white police man asks whose car it is and Mr. Wilbert tells him its his. But the police officer accuses Mr Wilbert of lying. As you can see the real prejudice of white people is coming out and you can see how they are treating him. This is the real first time ‘Lois has feared this much because she never has felt the full on effects of racism and prejudice acts. The family had lost their relatives or they would have not been enquired by the policeman like this. The policeman would have thought twice about pulling over this car. Njabulo was married to Thebedi but Thebedi didnt tell a single word to Paulus about this and this was the end of their unlawful relationship. A baby was born within two months after their marriage and this was not a shame because it was custom for the husband to check if his wife is not ‘barren. The baby however was mixed race, so Paulus ends up killing the baby. Thebedi took this case to court, which was the first time she went outside the farm. She claimed he had murdered the baby. Paulus claimed his innocence; Thebedi was becoming weaker, ‘she cried hysterically. As time was passing, she couldnt control her emotions. It was up to Njabulo to protect her and give her confidence but on the second trial of the court, Thebedi doesnt say anything. This can be reasoned to the fact that she has accepted the death of her baby and that live always moves on. Wilbert had been released and he decided to go back, he kept on going out of the southern states but he was getting very tired, so he pulled into a grove of trees and fell asleep. ‘Lois on the other hand was terrified and couldnt fall to sleep. She was so scared and she wanted to protect her family. ‘I took hold of it, she was so scared that she had taken hold of a ‘sharp knife and she was ‘ready to strike. The Cadillac is brand new and gold in colour. It shows that the black family who owns it is no longer poor and downtrodden. The car highlights the conflict in the story. There are two main areas of conflict in the family and in society as a whole. Racism effects people in many ways and many people havent felt the full on effect of racism but the reaction we get from Mr Wilbert and Thebedi is acceptance of racism. Both of them get affected by racism. ‘Lois had felt a strong force called racism at a young age so she will know what racism is and how it affects people, she will always remember it. Even though ‘Lois mum said Wilbert could keep the car, Mr. Wilbert went out and sold the car and came back home walking. All the neighbours thought he had lost most his money but this was not the reason, the reason was to pull his family together again. So they were the closest family. The death of the mixed race baby was not all the fault of Paulus it was the fault of Thebedi as well. She knew what he was going to do, but she didnt stop him. She just stood outside waiting for him to finish. She never went to look at the baby on that day. She had accepted it. If she had stopped him, she would have had a baby now but she had accepted that life was life and that racism and prejudice was everywhere in South Africa. Mr. Wilbert could have also ceased the opportunity tom not show ‘Lois what racism was like, but he didnt and she felt the full on effect of racism and also did he. Here we see racism affects man, woman, boy, girl and even a baby. Racism and prejudice views affect everyone. The Gold Cadillac causes conflict within the family. It impresses the local black community. It causes and exposes jealousy. The car provides a learning experience to Wilbert and ‘Lois who tackle racism for the first time. I think the car finally makes the family stronger and makes their bonds more rigid. Nadine Gordimer shows us how black people had been treated unfairly. She portrays racism to us directly as the script is in 3rd person. I have learnt that racism is all around us in this world. Even the minority of people in one country can affect the majority of people. Education is a key factor in society and in ways to tackle racism. Without education you are always inferior and will be seen as a servant. Both stories are perfect examples of racism and prejudice believes. I think both stories show the reader how racism is felt, but I feel that The Gold Cadillac has a stronger source for racism because Lois has told more from her narration. From ‘The Gold Cadillac Lois being a narrator helped me understand the story better because we can see how she feels when something happens, it looks like your just standing next to Lois when she narrates and I can see a better understanding of the text. In ‘Country Lovers I feel the story was more on love than racism. When Njabulo falls in love with Thebedi is another long paragraph on love. The Immortality act which represents ‘Country Lovers was quite a strong racial point. But still I believe ‘The Gold Cadillac revealed more racism.

Wednesday, November 13, 2019

Attention Climbing Hold Consumers :: Economy Consumerism Essays

Attention Climbing Hold Consumers The climbing hold industry can be a complicated world. There are so many different companies that make a lot of the same products. In this paper it will be discussed what a consumer can look for in a website to determine if the climbing hold company would be the right one for them. Three companies of different sizes were researched when doing this comparison. The first company that will be looked at is Edge Climbing Walls System. This is a real small company based out of Canada. They are a company that has little direct effect on the market, but many other companies like it as whole are having a large impact on the market. The second company that will be discussed is a company that is on its way up in the industry. They have been in business for a few years but seem to be having a large share of the market. Morganic holds is an Iowa based company, believe it or not, that got its start in a dingy garage in Nevada, Iowa. The last one is Nicros. Nicros is the world’s largest manufacture and distributor of climbing holds. They have been in business for many years and distribute holds globally. When looking at Edge Walls website it can be seen as a small company. The website is only one page. There are also very little links to other of there own pages. When first entering the site, the name of the company is not on the top of the page for easy viewing. Displaying the company name at the top of a webpage would be a lot more useful. When scrolling down the page it next list the uniqueness of there company. They discuss why they feel that they have a good product and whose opinion that might be. Next part of the page climbing hold can be seen. When scrolling down more holds appear. On the page the holds are displayed in a format that can be deceiving to the eye. When scrolling down the holds become a blur of color.